publications publications

Joint publications:


Aguzzi Group


Krützfeldt Group


Krützfeldt J, Rajewsky N, Braich R, Rajeev KG, Tuschl T, Manoharan M, Stoffel M. Silencing of microRNAs in vivo with 'antagomirs'. Nature. 2005 Dec 1;438(7068):685-9.

Krützfeldt J, Poy MN, Stoffel M. Strategies to determine the biological function of microRNAs. Nat Genet. 2006 Jun;38 Suppl 1:S14-9.

Krützfeldt J, Stoffel M. MicroRNAs: A new class of regulatory genes affecting metabolism. Cell Metab. 2006 Jul;4(1):9-12.

Krützfeldt J, Kuwajima S, Braich R, Rajeev KG, Pena J, Tuschl T, Manoharan M, Stoffel M. Specificity, duplex degradation and subcellular localization of antagomirs. Nucleic Acids Res. 2007 April; 35(9):2885-92.

Krützfeldt J, Rösch N, Hausser J, Manoharan M, Zavolan M, Stoffel M. MicroRNA-194 is a target of transcription factor 1 (Tcf1, Hnf1α) in adult liver and controls expression of frizzled-6. Hepatology. 2012 Jan;55(1):98-107.


Polymenidou M*, Lagier-Tourenne C*, Hutt KR*, Huelga SC, Moran J, Liang TY, Ling SC, Sun E, Wancewicz E, Mazur C, Kordasiewicz H, Sedaghat Y, Donohue JP, Shiue L, Bennett CF, Yeo GW, Cleveland DW (2011) Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43. Nature Neurosc, 14, 459–468 [*equal contribution]

Polymenidou M, Cleveland DW (2011) The Seeds of Neurodegeneration: Prion-like Spreading in ALS. Cell, 147, 498-508

Polymenidou M, Cleveland DW (2012) Prion-like spread of protein aggregates in neurodegeneration. Journal of Exp Med, 209, 889-93

Lagier-Tourenne C*, Polymenidou M*, Hutt KR*, Vu AQ, Clutario K, Baughn M, Huelga SC, Ling SC, Liang TY, Mazur C, Wancewicz E, Kim AS, Watt A, Freier S, Hicks GG, Donohue JP, Shiue L, Bennett CF, Ravits J, Cleveland DW and Yeo GW (2012) Divergent roles of ALS-linked proteins FUS/TLS and TDP-43 intersect in processing long pre-mRNAs. Nature Neurosc, 15, 1488-97 [*equal contribution]

Lagier-Tourenne C, Baughn M, Rigo F, Sun S, Liu P, Li HR, Jiang J, Watt AT, Chun S, Katz M, Qiu J, Sun Y, Ling S-C, Zhu Q, Polymenidou M, Drenner K, Artates JW, McAlonis-Downes M, Markmiller S, Hutt KR, Pizzo DP, Cady J, Harms MB, Baloh RH, Vandenberg SR, Yeo GW, Fu X-D, Bennett CF, Cleveland DW, Ravits J (2013) Targeted degradation of sense and antisense C9orf72 RNA foci as therapy for ALS and frontotemporal degeneration. PNAS, 110, 47, E4530-39

Stoffel Group

Selected publications

LaPierre MP and Stoffel M (2017). MicroRNAs as stress regulators in pancreatic beta cells and diabetes. Molecular Metabolism 6:1010-1023.

Landmesser Group


Shroff, R. et al. HDL in Children with CKD Promotes Endothelial Dysfunction and an Abnormal Vascular Phenotype. Journal of the American Society of Nephrology : JASN 25, 2658-2668, doi:10.1681/ASN.2013111212 (2014).

Landmesser, U. Coronary artery disease: HDL and coronary heart disease--novel insights. Nature reviews. Cardiology 11, 559-560, doi:10.1038/nrcardio.2014.128 (2014).

Kratzer, A., Giral, H. & Landmesser, U. High-density lipoproteins as modulators of endothelial cell functions: alterations in patients with coronary artery disease. Cardiovascular research 103, 350-361, doi:10.1093/cvr/cvu139 (2014).

Krankel, N., Luscher, T. F. & Landmesser, U. Novel insights into vascular repair mechanisms. Current pharmaceutical design 20, 2430-2438 (2014).

Full list of publications

Kyburz Group

Kyburz D, Karouzakis E, Ospelt C. Epigenetic changes: the missing link. Best Pract Res Clin Rheumatol. 2014 Aug;28(4):577-587.