The general goal of Magdalini Polymenidou's research is to understand the molecular mechanisms leading to neurodegenerative disorders, such as Amyotrophic Lateral Sclerosis (ALS) and Frontotemporal Lobar Degeneration (FTLD). Her research group is focusing on deciphering the consequences of 1) protein aggregation, and 2) errors in RNA homeostasis, triggered by the misregulation of ALS/FTLD-linked proteins, such as TDP-43, FUS/TLS, SOD1, and the newly identified protein of unknown properties, tentatively called C9orf72. These questions are studied by combining high-throughput sequencing with basic biochemistry methods and organotypic slice cultures as well as human cells.
Prof. Polymenidou joined the consortium in January 2014. She replaces Prof. Kyburz who accepted a professorship at the University of Basel.